
                                SEQUENCE LISTING

<110> Merck & Co., Inc.
      An, Zhiqiang
      Chen, Fang
      Fisher, John E.
      Glantschnig, Helmut
      Kimmel, Donald B.
      Reszka, Alfred
      Wang, Fubao

<120> ANTIBODIES SPECIFIC FOR DKK-1
  

<130> PCT-22295

<150> 60/900,226          
<151> 2007-02-08  

<160> 71

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody Light Chain DNA Sequence

<400> 1
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgc 60
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc 120
tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag 180
cttccaggaa cagcccccaa actcctcatc tatggttaca gcaatcggcc ctcaggggtc 240
cctgaccgat tctctggctc caagtctggc gcctcagcct ccctggccat cactgggctc 300
cggcctgacg atgaggctga ttactattgc cagtcctatg acaacagcct gagttcttat 360
gtcttcggag gtgggaccca gctcaccgtt ttaagtcagc ccaaggccaa ccccaccgtg 420
accctgttcc ccccatcttc tgaggagctg caagccaaca aggccaccct ggtgtgcctg 480
atctctgact tctaccctgg cgctgtgaca gtggcctgga aggctgatgg ctctcctgtg 540
aaggctggcg tggagaccac caagccatct aagcagtcta acaacaagta tgctgcctct 600
tcttacctgt ctctgacccc tgagcagtgg aagagccacc ggtcttactc ttgccaggtg 660
acccatgagg gctctacagt ggagaagaca gtggccccca cagagtgctc ttga       714

<210> 2
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody Light Chain Amino Acid Sequence

<400> 2
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly
            20                  25                  30          
Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn
        35                  40                  45              
Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Gly Tyr Ser Asn Arg Pro Ser Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala
                85                  90                  95      
Ile Thr Gly Leu Arg Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
            100                 105                 110         
Tyr Asp Asn Ser Leu Ser Ser Tyr Val Phe Gly Gly Gly Thr Gln Leu
        115                 120                 125             
Thr Val Leu Ser Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 3
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody Light Chain Amino Acid Sequence
      without leader

<400> 3
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Tyr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Arg Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Ser Ser Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser
            100                 105                 110         
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
            180                 185                 190         
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215         


<210> 4
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody light chain variable region
      sequence

<400> 4
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Tyr Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Ala Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Arg Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Ser Ser Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ser
            100                 105                 110         


<210> 5
<211> 1374
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody Heavy Chain DNA Sequence

<400> 5
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactcggag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccgac tactatatac actgggtgcg acaggcccct 180
ggacaagggc ttgagtggat gggatggatc cactctaaca gtggcgccac aacctatgca 240
cagaagtttc aggccagggt caccatgagc agggacacgt ccagcagcac agcctacatg 300
gagttgagca ggctggaatc tgacgacacg gccatgtatt tttgttcgag agaggactac 360
tggggccaag gaaccctggt caccgtctcg agtgcatcca ccaagggccc atccgtcttc 420
cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc 480
aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 540
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 600
accgtgacct ccagcaactt tggcacgcag acctacacct gcaacgtaga tcacaagccc 660
agcaacacca aggtggacaa gacagttgag cggaaatgct gcgtggagtg cccaccatgc 720
ccagcacctc cagtggccgg accatcagtc ttcctgttcc ccccaaaacc caaggacact 780
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 840
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 900
ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac 960
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 1020
tccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagagccaca ggtgtacacc 1080
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa 1140
ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac 1200
tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagcta 1260
accgtggaca agagcaggtg gcagcagggg aatgtcttct catgctccgt gatgcatgag 1320
gctctgcaca accactacac acagaagagc ctctccctgt ctcctggtaa atga       1374

<210> 6
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody Heavy Chain Amino Acid Sequence

<400> 6
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Asp Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met
            100                 105                 110         
Tyr Phe Cys Ser Arg Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly
        195                 200                 205             
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270         
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        275                 280                 285             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300                 
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335     
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            340                 345                 350         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455         


<210> 7
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> Rh2-18 Antibody Heavy Chain Amino Acid Sequence
      without leader

<400> 7
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
        115                 120                 125             
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
    130                 135                 140                 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
145                 150                 155                 160 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
            180                 185                 190         
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
        195                 200                 205             
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
225                 230                 235                 240 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                245                 250                 255     
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
            260                 265                 270         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
        275                 280                 285             
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    290                 295                 300                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
305                 310                 315                 320 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
                325                 330                 335     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
            340                 345                 350         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        355                 360                 365             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    370                 375                 380                 
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
385                 390                 395                 400 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                405                 410                 415     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            420                 425                 430         
Ser Leu Ser Pro Gly Lys
        435             


<210> 8
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Rh2-18 heavy chain variable region

<400> 8
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110 


<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 HC CDR1

<400> 9
Asp Tyr Tyr Ile His
 1               5  


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 HC CDR2

<400> 10
Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe Gln
 1               5                  10                  15      
Ala
    


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 HC CDR3

<400> 11
Glu Asp Tyr
 1          


<210> 12
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 LC CDR1

<400> 12
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His
 1               5                  10                  


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 LC CDR2

<400> 13
Gly Tyr Ser Asn Arg Pro Ser
 1               5          


<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-18 LC CDR3

<400> 14
Gln Ser Tyr Asp Asn Ser Leu Ser Ser Tyr Val
 1               5                  10      


<210> 15
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH1 1-3 1-02 heavy chain variable region

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 16
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL1 14-7A light chain variable region sequence

<400> 16
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Gly Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu
            100                 105                 110     


<210> 17
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Light Chain DNA Sequence

<400> 17
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgc 60
cagtctgtgc tgactcagcc accctcagcg tctggggccc cagggcagag ggtcaccatc 120
tcctgcactg ggagcagctc caacatcggg gctggttatg atgtacactg gtaccagcag 180
cttccaggag cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc 240
cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc 300
caggctgagg atgaggctga ttattattgc cagtcctatg acagcagcct gagtggttat 360
gtcttcggaa ctgggaccaa ggtcaccgtc ctaggtcagc ccaaggccaa ccccaccgtg 420
accctgttcc ccccatcttc tgaggagctg caagccaaca aggccaccct ggtgtgcctg 480
atctctgact tctaccctgg cgctgtgaca gtggcctgga aggctgatgg ctctcctgtg 540
aaggctggcg tggagaccac caagccatct aagcagtcta acaacaagta tgctgcctct 600
tcttacctgt ctctgacccc tgagcagtgg aagagccacc ggtcttactc ttgccaggtg 660
acccatgagg gctctacagt ggagaagaca gtggccccca cagagtgctc ttga       714

<210> 18
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Light Chain Amino Acid Sequence

<400> 18
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly
            20                  25                  30          
Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn
        35                  40                  45              
Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala
                85                  90                  95      
Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
            100                 105                 110         
Tyr Asp Ser Ser Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val
        115                 120                 125             
Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 19
<211> 1374
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Heavy Chain DNA Sequence

<400> 19
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactcgcag 60
gtgcagctgt tgcagtctgc agcagaggtg aaaaagcccg gggagtctct gaagatctcc 120
tgtaagggtt ctggatacga ctttcccggc tactatctgc actgggtgcg acaggcccct 180
ggacaaggcc ttgagtggat gggctggatc aacgctaaca gtggtgccac aaattatgca 240
cagaactttc agggcagggt caccatgacc agggacacgt ccatcagcgc agcttacatg 300
gagctgagca gcctgagatc tgacgacacg gccgtctatt attgtacgag agaggaccac 360
tggggccgag ggaccacggt caccgtctcc tcagcatcca ccaagggccc atccgtcttc 420
cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc 480
aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 540
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 600
accgtgacct ccagcaactt tggcacgcag acctacacct gcaacgtaga tcacaagccc 660
agcaacacca aggtggacaa gacagttgag cggaaatgct gcgtggagtg cccaccatgc 720
ccagcacctc cagtggccgg accatcagtc ttcctgttcc ccccaaaacc caaggacact 780
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 840
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 900
ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac 960
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 1020
tccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagagccaca ggtgtacacc 1080
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa 1140
ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac 1200
tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagcta 1260
accgtggaca agagcaggtg gcagcagggg aatgtcttct catgctccgt gatgcatgag 1320
gctctgcaca accactacac acagaagagc ctctccctgt ctcctggtaa atga       1374

<210> 20
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Heavy Chain Amino Acid Sequence

<400> 20
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Gln Val Gln Leu Leu Gln Ser Ala Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe
        35                  40                  45              
Pro Gly Tyr Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile Asn Ala Asn Ser Gly Ala Thr Asn Tyr Ala
65                  70                  75                  80  
Gln Asn Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser
                85                  90                  95      
Ala Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Thr Arg Glu Asp His Trp Gly Arg Gly Thr Thr Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly
        195                 200                 205             
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270         
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        275                 280                 285             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300                 
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335     
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            340                 345                 350         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455         


<210> 21
<211> 700
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Light Chain DNA Sequence

<400> 21
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgc 60
caggctgtgc tgactcagcc gtcctcagtg tctggggccc cagggcagag ggtcaccatc 120
tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag 180
cttccaggaa cagcccccaa actcctcatc tatgctaaca ccaatcggcc ctcagggatc 240
cctgaccgat tctctggctc caagtctggc acctcggcct ccctggccat cactgggctc 300
cagactgagg atgaggctga ttattactgc cagtcctatg acaccagccc gagtgcctct 360
tatgtcttcg gaactgggac caagctgacc gtcctaggtc agcccaaggc caaccccacc 420
gtgaccctgt tccccccatc ttctgaggag ctgcaagcca acaaggccac cctggtgtgc 480
ctgatctctg acttctaccc tggcgctgtg acagtggcct ggaaggctga tggctctcct 540
gtgaaggctg gcgtggagac caccaagcca tctaagcagt ctaacaacaa gtatgctgcc 600
tcttcttacc tgtctctgac ccctgagcag tggaagagcc accggtctta ctcttgccag 660
gtgacccatg agggctctac agtggagaag acagtggccc                       700

<210> 22
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Light Chain Amino Acid Sequence

<400> 22
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly
            20                  25                  30          
Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn
        35                  40                  45              
Ile Gly Ala Gly Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Ala Asn Thr Asn Arg Pro Ser Gly Ile
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala
                85                  90                  95      
Ile Thr Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
            100                 105                 110         
Tyr Asp Thr Ser Pro Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys
        115                 120                 125             
Leu Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe
    130                 135                 140                 
Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys
145                 150                 155                 160 
Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala
                165                 170                 175     
Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys
            180                 185                 190         
Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro
        195                 200                 205             
Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu
    210                 215                 220                 
Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235             


<210> 23
<211> 1374
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Heavy Chain DNA Sequence

<400> 23
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactcggaa 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccgac tactatatac actgggtgcg acaggcccct 180
ggacaagggc ttgagtggat gggatggatc cactctaaca gtggcgccac aacctatgca 240
cagaagtttc aggccagggt caccatgagc agggacacgt ccagcagcac agcctacatg 300
gagttgagca ggctggaatc tgacgacacg gccatgtatt tttgttcgag agaggactac 360
tggggcagag ggacaatggt caccgtctcg agtgcatcca ccaagggccc atccgtcttc 420
cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc 480
aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 540
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 600
accgtgacct ccagcaactt tggcacgcag acctacacct gcaacgtaga tcacaagccc 660
agcaacacca aggtggacaa gacagttgag cggaaatgct gcgtggagtg cccaccatgc 720
ccagcacctc cagtggccgg accatcagtc ttcctgttcc ccccaaaacc caaggacact 780
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 840
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 900
ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac 960
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 1020
tccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagagccaca ggtgtacacc 1080
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa 1140
ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac 1200
tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagcta 1260
accgtggaca agagcaggtg gcagcagggg aatgtcttct catgctccgt gatgcatgag 1320
gctctgcaca accactacac acagaagagc ctctccctgt ctcctggtaa atga       1374

<210> 24
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Heavy Chain Amino Acid Sequence

<400> 24
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Asp Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met
            100                 105                 110         
Tyr Phe Cys Ser Arg Glu Asp Tyr Trp Gly Arg Gly Thr Met Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly
        195                 200                 205             
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270         
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        275                 280                 285             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300                 
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335     
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            340                 345                 350         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455         


<210> 25
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Light Chain DNA Sequence

<400> 25
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacaga tgccagatgc 60
caggctgtgc tgactcagcc gtcctcagtg tctggggccc cagggcagag ggtctccatc 120
tcctgcactg ggagcagctc caacatcggg gcagcttatg atgtacactg gtaccagcag 180
cttccaggaa cagcccccag actcctcatc tatgttaaca acaatcggcc ctcaggggtc 240
cctgaccgat tctctggctc caagtcgggc acctcagcct ccctagtcat tgctgggctc 300
caggctgagg atgaggctga ttattactgc cagtcctatg acaatagtct gaatgcttat 360
gtcttcggaa ctgggaccaa gctgaccgtc ctaggtcagc ccaaggccaa ccccaccgtg 420
accctgttcc ccccatcttc tgaggagctg caagccaaca aggccaccct ggtgtgcctg 480
atctctgact tctaccctgg cgctgtgaca gtggcctgga aggctgatgg ctctcctgtg 540
aaggctggcg tggagaccac caagccatct aagcagtcta acaacaagta tgctgcctct 600
tcttacctgt ctctgacccc tgagcagtgg aagagccacc ggtcttactc ttgccaggtg 660
acccatgagg gctctacagt ggagaagaca gtggccccca cagagtgctc ttga       714

<210> 26
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Light Chain Amino Acid Sequence

<400> 26
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly
            20                  25                  30          
Ala Pro Gly Gln Arg Val Ser Ile Ser Cys Thr Gly Ser Ser Ser Asn
        35                  40                  45              
Ile Gly Ala Ala Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr
    50                  55                  60                  
Ala Pro Arg Leu Leu Ile Tyr Val Asn Asn Asn Arg Pro Ser Gly Val
65                  70                  75                  80  
Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val
                85                  90                  95      
Ile Ala Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser
            100                 105                 110         
Tyr Asp Asn Ser Leu Asn Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu
        115                 120                 125             
Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro
    130                 135                 140                 
Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu
145                 150                 155                 160 
Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp
                165                 170                 175     
Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln
            180                 185                 190         
Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu
        195                 200                 205             
Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly
    210                 215                 220                 
Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
225                 230                 235         


<210> 27
<211> 1374
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Heavy Chain DNA Sequence

<400> 27
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactcggag 60
gtgcagctgg tgcagtctgg ggctgaggtg aagaagcctg gggcctcagt gaaggtctcc 120
tgcaaggctt ctggatacac cttcaccgac tactatatac actgggtgcg acaggcccct 180
ggacaagggc ttgagtggat gggatggatc cactctaaca gtggcgccac aacctatgca 240
cagaagtttc aggccagggt caccatgagc agggacacgt ccagcagcac agcctacatg 300
gagttgagca ggctggaatc tgacgacacg gccatgtatt tttgttcgag agaggactac 360
tggggcaaag ggacaatggt caccgtctcg agtgcatcca ccaagggccc atccgtcttc 420
cccctggcgc cctgctccag gagcacctcc gagagcacag ccgccctggg ctgcctggtc 480
aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 540
gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 600
accgtgacct ccagcaactt tggcacgcag acctacacct gcaacgtaga tcacaagccc 660
agcaacacca aggtggacaa gacagttgag cggaaatgct gcgtggagtg cccaccatgc 720
ccagcacctc cagtggccgg accatcagtc ttcctgttcc ccccaaaacc caaggacact 780
ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac 840
cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag 900
ccgcgggagg agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgtcctgcac 960
caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc 1020
tccatcgaga aaaccatctc caaaaccaaa gggcagcccc gagagccaca ggtgtacacc 1080
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa 1140
ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac 1200
tacaagacca cgcctcccat gctggactcc gacggctcct tcttcctcta cagcaagcta 1260
accgtggaca agagcaggtg gcagcagggg aatgtcttct catgctccgt gatgcatgag 1320
gctctgcaca accactacac acagaagagc ctctccctgt ctcctggtaa atga       1374

<210> 28
<211> 457
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Heavy Chain Amino Acid Sequence

<400> 28
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
        35                  40                  45              
Thr Asp Tyr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
    50                  55                  60                  
Glu Trp Met Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala
65                  70                  75                  80  
Gln Lys Phe Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met
            100                 105                 110         
Tyr Phe Cys Ser Arg Glu Asp Tyr Trp Gly Lys Gly Thr Met Val Thr
        115                 120                 125             
Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro
    130                 135                 140                 
Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val
145                 150                 155                 160 
Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                165                 170                 175     
Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly
            180                 185                 190         
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly
        195                 200                 205             
Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys
    210                 215                 220                 
Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys
225                 230                 235                 240 
Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
                245                 250                 255     
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            260                 265                 270         
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr
        275                 280                 285             
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    290                 295                 300                 
Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His
305                 310                 315                 320 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                325                 330                 335     
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln
            340                 345                 350         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met
        355                 360                 365             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    370                 375                 380                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
385                 390                 395                 400 
Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu
                405                 410                 415     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            420                 425                 430         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        435                 440                 445             
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    450                 455         


<210> 29
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leader sequence for heavy chain

<400> 29
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Leader sequence for light chain

<400> 30
Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr
 1               5                  10                  15      
Asp Ala Arg Cys
            20  


<210> 31
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer, heavy chain forward

<400> 31
acaggtgtcc actcggaggt gcagctggtg cagtct                           36

<210> 32
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer, heavy chain reverse

<400> 32
gcccttggtg gatgcactcg agacggtgac cagggt                           36

<210> 33
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer, light chain forward

<400> 33
acagatgcca gatgccagtc tgtgttgacg cagccg                           36

<210> 34
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> PCR primer, light chain reverse

<400> 34
gttggccttg ggctgactta aaacggtgag ctgggt                           36

<210> 35
<211> 266
<212> PRT
<213> Homo Sapien

<220> 
<221> VARIANT        
<222> (1)...(266)
<223> Dkk-1 precursor

<400> 35
Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met
 1               5                  10                  15      
Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr
            20                  25                  30          
Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro
        35                  40                  45              
Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro
    50                  55                  60                  
Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr
65                  70                  75                  80  
Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr
                85                  90                  95      
Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu
            100                 105                 110         
Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys
        115                 120                 125             
Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn
    130                 135                 140                 
His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn
145                 150                 155                 160 
Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser
                165                 170                 175     
Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser
            180                 185                 190         
Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys
        195                 200                 205             
Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg
    210                 215                 220                 
Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly
225                 230                 235                 240 
Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn
                245                 250                 255     
Ser Ser Arg Leu His Thr Cys Gln Arg His
            260                 265     


<210> 36
<211> 259
<212> PRT
<213> Homo Sapien

<220> 
<221> VARIANT        
<222> (1)...(259)
<223> Dkk-2 precursor

<400> 36
Met Ala Ala Leu Met Arg Ser Lys Asp Ser Ser Cys Cys Leu Leu Leu
 1               5                  10                  15      
Leu Ala Ala Val Leu Met Val Glu Ser Ser Gln Ile Gly Ser Ser Arg
            20                  25                  30          
Ala Lys Leu Asn Ser Ile Lys Ser Ser Leu Gly Gly Glu Thr Pro Gly
        35                  40                  45              
Gln Ala Ala Asn Arg Ser Ala Gly Met Tyr Gln Gly Leu Ala Phe Gly
    50                  55                  60                  
Gly Ser Lys Lys Gly Lys Asn Leu Gly Gln Ala Tyr Pro Cys Ser Ser
65                  70                  75                  80  
Asp Lys Glu Cys Glu Val Gly Arg Tyr Cys His Ser Pro His Gln Gly
                85                  90                  95      
Ser Ser Ala Cys Met Val Cys Arg Arg Lys Lys Lys Arg Cys His Arg
            100                 105                 110         
Asp Gly Met Cys Cys Pro Ser Thr Arg Cys Asn Asn Gly Ile Cys Ile
        115                 120                 125             
Pro Val Thr Glu Ser Ile Leu Thr Pro His Ile Pro Ala Leu Asp Gly
    130                 135                 140                 
Thr Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu
145                 150                 155                 160 
Gly Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys
                165                 170                 175     
Gly His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly
            180                 185                 190         
Phe Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu
        195                 200                 205             
His Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly
    210                 215                 220                 
Leu Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys
225                 230                 235                 240 
Val Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys
                245                 250                 255     
Gln Lys Ile
            


<210> 37
<211> 224
<212> PRT
<213> Homo Sapien

<220> 
<221> VARIANT        
<222> (1)...(224)
<223> Dkk-4 precursor

<400> 37
Met Val Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu
 1               5                  10                  15      
Gly Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu
            20                  25                  30          
His Gly Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn
        35                  40                  45              
Thr Arg Lys Phe Cys Leu Gln Pro Arg Asp Glu Lys Pro Phe Cys Ala
    50                  55                  60                  
Thr Cys Arg Gly Leu Arg Arg Arg Cys Gln Arg Asp Ala Met Cys Cys
65                  70                  75                  80  
Pro Gly Thr Leu Cys Val Asn Asp Val Cys Thr Thr Met Glu Asp Ala
                85                  90                  95      
Thr Pro Ile Leu Glu Arg Gln Leu Asp Glu Gln Asp Gly Thr His Ala
            100                 105                 110         
Glu Gly Thr Thr Gly His Pro Val Gln Glu Asn Gln Pro Lys Arg Lys
        115                 120                 125             
Pro Ser Ile Lys Lys Ser Gln Gly Arg Lys Gly Gln Glu Gly Glu Ser
    130                 135                 140                 
Cys Leu Arg Thr Phe Asp Cys Gly Pro Gly Leu Cys Cys Ala Arg His
145                 150                 155                 160 
Phe Trp Thr Lys Ile Cys Lys Pro Val Leu Leu Glu Gly Gln Val Cys
                165                 170                 175     
Ser Arg Arg Gly His Lys Asp Thr Ala Gln Ala Pro Glu Ile Phe Gln
            180                 185                 190         
Arg Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser Gln Leu Thr Ser
        195                 200                 205             
Asn Arg Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile Glu Lys Leu
    210                 215                 220                 


<210> 38
<211> 250
<212> PRT
<213> Maccaca Mulatta

<220> 
<221> VARIANT        
<222> (1)...(250)
<223> Dkk-1 precursor

<400> 38
Met Met Ala Leu Gly Ala Ala Gly Ala Ala Arg Val Leu Val Ala Leu
 1               5                  10                  15      
Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr Asn
            20                  25                  30          
Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro Gly Gly
        35                  40                  45              
Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro Ile Leu Tyr
    50                  55                  60                  
Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr Pro Tyr Pro Cys
65                  70                  75                  80  
Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr Ala Ser Pro Thr Arg
                85                  90                  95      
Gly Gly Asp Ala Gly Val Gln Ile Cys Leu Cys Arg Lys Arg Arg Lys
            100                 105                 110         
Arg Cys Met Arg His Ala Met Cys Cys Gly Asn Tyr Cys Lys Asn Gly
        115                 120                 125             
Ile Cys Val Ser Ser Asp Gln Asn Phe Arg Gly Glu Ile Glu Glu Thr
    130                 135                 140                 
Ile Thr Glu Ser Phe Gly Asn His Ser Thr Leu Asp Gly Tyr Ser Arg
145                 150                 155                 160 
Arg Thr Thr Leu Ser Ser Met Tyr His Ser Lys Gly Gln Glu Gly Ser
                165                 170                 175     
Val Cys Leu Arg Ser Asp Cys Ala Thr Gly Leu Cys Cys Ala Arg His
            180                 185                 190         
Phe Trp Ser Lys Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr
        195                 200                 205             
Lys His Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr
    210                 215                 220                 
Cys Gly Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser
225                 230                 235                 240 
Asn Ser Arg Leu His Thr Cys Gln Arg His
                245                 250 


<210> 39
<211> 1615
<212> PRT
<213> Homo Sapien

<220> 
<221> VARIANT        
<222> (1)...(1615)
<223> LRP5

<400> 39
Met Glu Ala Ala Pro Pro Gly Pro Pro Trp Pro Leu Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Leu Ala Leu Cys Gly Cys Pro Ala Pro Ala Ala Ala Ser
            20                  25                  30          
Pro Leu Leu Leu Phe Ala Asn Arg Arg Asp Val Arg Leu Val Asp Ala
        35                  40                  45              
Gly Gly Val Lys Leu Glu Ser Thr Ile Val Val Ser Gly Leu Glu Asp
    50                  55                  60                  
Ala Ala Ala Val Asp Phe Gln Phe Ser Lys Gly Ala Val Tyr Trp Thr
65                  70                  75                  80  
Asp Val Ser Glu Glu Ala Ile Lys Gln Thr Tyr Leu Asn Gln Thr Gly
                85                  90                  95      
Ala Ala Val Gln Asn Val Val Ile Ser Gly Leu Val Ser Pro Asp Gly
            100                 105                 110         
Leu Ala Cys Asp Trp Val Gly Lys Lys Leu Tyr Trp Thr Asp Ser Glu
        115                 120                 125             
Thr Asn Arg Ile Glu Val Ala Asn Leu Asn Gly Thr Ser Arg Lys Val
    130                 135                 140                 
Leu Phe Trp Gln Asp Leu Asp Gln Pro Arg Ala Ile Ala Leu Asp Pro
145                 150                 155                 160 
Ala His Gly Tyr Met Tyr Trp Thr Asp Trp Gly Glu Thr Pro Arg Ile
                165                 170                 175     
Glu Arg Ala Gly Met Asp Gly Ser Thr Arg Lys Ile Ile Val Asp Ser
            180                 185                 190         
Asp Ile Tyr Trp Pro Asn Gly Leu Thr Ile Asp Leu Glu Glu Gln Lys
        195                 200                 205             
Leu Tyr Trp Ala Asp Ala Lys Leu Ser Phe Ile His Arg Ala Asn Leu
    210                 215                 220                 
Asp Gly Ser Phe Arg Gln Lys Val Val Glu Gly Ser Leu Thr His Pro
225                 230                 235                 240 
Phe Ala Leu Thr Leu Ser Gly Asp Thr Leu Tyr Trp Thr Asp Trp Gln
                245                 250                 255     
Thr Arg Ser Ile His Ala Cys Asn Lys Arg Thr Gly Gly Lys Arg Lys
            260                 265                 270         
Glu Ile Leu Ser Ala Leu Tyr Ser Pro Met Asp Ile Gln Val Leu Ser
        275                 280                 285             
Gln Glu Arg Gln Pro Phe Phe His Thr Arg Cys Glu Glu Asp Asn Gly
    290                 295                 300                 
Gly Cys Ser His Leu Cys Leu Leu Ser Pro Ser Glu Pro Phe Tyr Thr
305                 310                 315                 320 
Cys Ala Cys Pro Thr Gly Val Gln Leu Gln Asp Asn Gly Arg Thr Cys
                325                 330                 335     
Lys Ala Gly Ala Glu Glu Val Leu Leu Leu Ala Arg Arg Thr Asp Leu
            340                 345                 350         
Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile Val Leu Gln
        355                 360                 365             
Val Asp Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp Pro Leu Glu
    370                 375                 380                 
Gly Tyr Val Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile Arg Arg Ala
385                 390                 395                 400 
Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Val Asn Thr Glu Ile Asn
                405                 410                 415     
Asp Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp
            420                 425                 430         
Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu Asn Gly Thr
        435                 440                 445             
Ser Arg Lys Ile Leu Val Ser Glu Asp Leu Asp Glu Pro Arg Ala Ile
    450                 455                 460                 
Ala Leu His Pro Val Met Gly Leu Met Tyr Trp Thr Asp Trp Gly Glu
465                 470                 475                 480 
Asn Pro Lys Ile Glu Cys Ala Asn Leu Asp Gly Gln Glu Arg Arg Val
                485                 490                 495     
Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu Asp Leu
            500                 505                 510         
Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys Ile Glu
        515                 520                 525             
Val Ile Asn Val Asp Gly Thr Lys Arg Arg Thr Leu Leu Glu Asp Lys
    530                 535                 540                 
Leu Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Phe Ile Tyr Trp
545                 550                 555                 560 
Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys Val Lys Ala
                565                 570                 575     
Ser Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly Leu Lys
            580                 585                 590         
Ala Val Asn Val Ala Lys Val Val Gly Thr Asn Pro Cys Ala Asp Arg
        595                 600                 605             
Asn Gly Gly Cys Ser His Leu Cys Phe Phe Thr Pro His Ala Thr Arg
    610                 615                 620                 
Cys Gly Cys Pro Ile Gly Leu Glu Leu Leu Ser Asp Met Lys Thr Cys
625                 630                 635                 640 
Ile Val Pro Glu Ala Phe Leu Val Phe Thr Ser Arg Ala Ala Ile His
                645                 650                 655     
Arg Ile Ser Leu Glu Thr Asn Asn Asn Asp Val Ala Ile Pro Leu Thr
            660                 665                 670         
Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Ser Asn Asn His
        675                 680                 685             
Ile Tyr Trp Thr Asp Val Ser Leu Lys Thr Ile Ser Arg Ala Phe Met
    690                 695                 700                 
Asn Gly Ser Ser Val Glu His Val Val Glu Phe Gly Leu Asp Tyr Pro
705                 710                 715                 720 
Glu Gly Met Ala Val Asp Trp Met Gly Lys Asn Leu Tyr Trp Ala Asp
                725                 730                 735     
Thr Gly Thr Asn Arg Ile Glu Val Ala Arg Leu Asp Gly Gln Phe Arg
            740                 745                 750         
Gln Val Leu Val Trp Arg Asp Leu Asp Asn Pro Arg Ser Leu Ala Leu
        755                 760                 765             
Asp Pro Thr Lys Gly Tyr Ile Tyr Trp Thr Glu Trp Gly Gly Lys Pro
    770                 775                 780                 
Arg Ile Val Arg Ala Phe Met Asp Gly Thr Asn Cys Met Thr Leu Val
785                 790                 795                 800 
Asp Lys Val Gly Arg Ala Asn Asp Leu Thr Ile Asp Tyr Ala Asp Gln
                805                 810                 815     
Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Met Ile Glu Ser Ser Asn
            820                 825                 830         
Met Leu Gly Gln Glu Arg Val Val Ile Ala Asp Asp Leu Pro His Pro
        835                 840                 845             
Phe Gly Leu Thr Gln Tyr Ser Asp Tyr Ile Tyr Trp Thr Asp Trp Asn
    850                 855                 860                 
Leu His Ser Ile Glu Arg Ala Asp Lys Thr Ser Gly Arg Asn Arg Thr
865                 870                 875                 880 
Leu Ile Gln Gly His Leu Asp Phe Val Met Asp Ile Leu Val Phe His
                885                 890                 895     
Ser Ser Arg Gln Asp Gly Leu Asn Asp Cys Met His Asn Asn Gly Gln
            900                 905                 910         
Cys Gly Gln Leu Cys Leu Ala Ile Pro Gly Gly His Arg Cys Gly Cys
        915                 920                 925             
Ala Ser His Tyr Thr Leu Asp Pro Ser Ser Arg Asn Cys Ser Pro Pro
    930                 935                 940                 
Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile Ser Arg Met Ile
945                 950                 955                 960 
Pro Asp Asp Gln His Ser Pro Asp Leu Ile Leu Pro Leu His Gly Leu
                965                 970                 975     
Arg Asn Val Lys Ala Ile Asp Tyr Asp Pro Leu Asp Lys Phe Ile Tyr
            980                 985                 990         
Trp Val Asp Gly Arg Gln Asn Ile Lys Arg Ala Lys Asp Asp Gly Thr
        995                 1000                1005            
Gln Pro Phe Val Leu Thr Ser Leu Ser Gln Gly Gln Asn Pro Asp Arg
    1010                1015                1020                
Gln Pro His Asp Leu Ser Ile Asp Ile Tyr Ser Arg Thr Leu Phe Trp
1025                1030                1035               1040 
Thr Cys Glu Ala Thr Asn Thr Ile Asn Val His Arg Leu Ser Gly Glu
                1045                1050                1055    
Ala Met Gly Val Val Leu Arg Gly Asp Arg Asp Lys Pro Arg Ala Ile
            1060                1065                1070        
Val Val Asn Ala Glu Arg Gly Tyr Leu Tyr Phe Thr Asn Met Gln Asp
        1075                1080                1085            
Arg Ala Ala Lys Ile Glu Arg Ala Ala Leu Asp Gly Thr Glu Arg Glu
    1090                1095                1100                
Val Leu Phe Thr Thr Gly Leu Ile Arg Pro Val Ala Leu Val Val Asp
1105                1110                1115               1120 
Asn Thr Leu Gly Lys Leu Phe Trp Val Asp Ala Asp Leu Lys Arg Ile
                1125                1130                1135    
Glu Ser Cys Asp Leu Ser Gly Ala Asn Arg Leu Thr Leu Glu Asp Ala
            1140                1145                1150        
Asn Ile Val Gln Pro Leu Gly Leu Thr Ile Leu Gly Lys His Leu Tyr
        1155                1160                1165            
Trp Ile Asp Arg Gln Gln Gln Met Ile Glu Arg Val Glu Lys Thr Thr
    1170                1175                1180                
Gly Asp Lys Arg Thr Arg Ile Gln Gly Arg Val Ala His Leu Thr Gly
1185                1190                1195               1200 
Ile His Ala Val Glu Glu Val Ser Leu Glu Glu Phe Ser Ala His Pro
                1205                1210                1215    
Cys Ala Arg Asp Asn Gly Gly Cys Ser His Ile Cys Ile Ala Lys Gly
            1220                1225                1230        
Asp Gly Thr Pro Arg Cys Ser Cys Pro Val His Leu Val Leu Leu Gln
        1235                1240                1245            
Asn Leu Leu Thr Cys Gly Glu Pro Pro Thr Cys Ser Pro Asp Gln Phe
    1250                1255                1260                
Ala Cys Ala Thr Gly Glu Ile Asp Cys Ile Pro Gly Ala Trp Arg Cys
1265                1270                1275               1280 
Asp Gly Phe Pro Glu Cys Asp Asp Gln Ser Asp Glu Glu Gly Cys Pro
                1285                1290                1295    
Val Cys Ser Ala Ala Gln Phe Pro Cys Ala Arg Gly Gln Cys Val Asp
            1300                1305                1310        
Leu Arg Leu Arg Cys Asp Gly Glu Ala Asp Cys Gln Asp Arg Ser Asp
        1315                1320                1325            
Glu Ala Asp Cys Asp Ala Ile Cys Leu Pro Asn Gln Phe Arg Cys Ala
    1330                1335                1340                
Ser Gly Gln Cys Val Leu Ile Lys Gln Gln Cys Asp Ser Phe Pro Asp
1345                1350                1355               1360 
Cys Ile Asp Gly Ser Asp Glu Leu Met Cys Glu Ile Thr Lys Pro Pro
                1365                1370                1375    
Ser Asp Asp Ser Pro Ala His Ser Ser Ala Ile Gly Pro Val Ile Gly
            1380                1385                1390        
Ile Ile Leu Ser Leu Phe Val Met Gly Gly Val Tyr Phe Val Cys Gln
        1395                1400                1405            
Arg Val Val Cys Gln Arg Tyr Ala Gly Ala Asn Gly Pro Phe Pro His
    1410                1415                1420                
Glu Tyr Val Ser Gly Thr Pro His Val Pro Leu Asn Phe Ile Ala Pro
1425                1430                1435               1440 
Gly Gly Ser Gln His Gly Pro Phe Thr Gly Ile Ala Cys Gly Lys Ser
                1445                1450                1455    
Met Met Ser Ser Val Ser Leu Met Gly Gly Arg Gly Gly Val Pro Leu
            1460                1465                1470        
Tyr Asp Arg Asn His Val Thr Gly Ala Ser Ser Ser Ser Ser Ser Ser
        1475                1480                1485            
Thr Lys Ala Thr Leu Tyr Pro Pro Ile Leu Asn Pro Pro Pro Ser Pro
    1490                1495                1500                
Ala Thr Asp Pro Ser Leu Tyr Asn Met Asp Met Phe Tyr Ser Ser Asn
1505                1510                1515               1520 
Ile Pro Ala Thr Val Arg Pro Tyr Arg Pro Tyr Ile Ile Arg Gly Met
                1525                1530                1535    
Ala Pro Pro Thr Thr Pro Cys Ser Thr Asp Val Cys Asp Ser Asp Tyr
            1540                1545                1550        
Ser Ala Ser Arg Trp Lys Ala Ser Lys Tyr Tyr Leu Asp Leu Asn Ser
        1555                1560                1565            
Asp Ser Asp Pro Tyr Pro Pro Pro Pro Thr Pro His Ser Gln Tyr Leu
    1570                1575                1580                
Ser Ala Glu Asp Ser Cys Pro Pro Ser Pro Ala Thr Glu Arg Ser Tyr
1585                1590                1595               1600 
Phe His Leu Phe Pro Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser
                1605                1610                1615


<210> 40
<211> 1613
<212> PRT
<213> Homo Sapien

<220> 
<221> VARIANT        
<222> (1)...(1613)
<223> LRP6

<400> 40
Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu
 1               5                  10                  15      
Leu Arg Ala Ala Pro Leu Leu Leu Tyr Ala Asn Arg Arg Asp Leu Arg
            20                  25                  30          
Leu Val Asp Ala Thr Asn Gly Lys Glu Asn Ala Thr Ile Val Val Gly
        35                  40                  45              
Gly Leu Glu Asp Ala Ala Ala Val Asp Phe Val Phe Ser His Gly Leu
    50                  55                  60                  
Ile Tyr Trp Ser Asp Val Ser Glu Glu Ala Ile Lys Arg Thr Glu Phe
65                  70                  75                  80  
Asn Lys Thr Glu Ser Val Gln Asn Val Val Val Ser Gly Leu Leu Ser
                85                  90                  95      
Pro Asp Gly Leu Ala Cys Asp Trp Leu Gly Glu Lys Leu Tyr Trp Thr
            100                 105                 110         
Asp Ser Glu Thr Asn Arg Ile Glu Val Ser Asn Leu Asp Gly Ser Leu
        115                 120                 125             
Arg Lys Val Leu Phe Trp Gln Glu Leu Asp Gln Pro Arg Ala Ile Ala
    130                 135                 140                 
Leu Asp Pro Ser Ser Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Val
145                 150                 155                 160 
Pro Lys Ile Glu Arg Ala Gly Met Asp Gly Ser Ser Arg Phe Ile Ile
                165                 170                 175     
Ile Asn Ser Glu Ile Tyr Trp Pro Asn Gly Leu Thr Leu Asp Tyr Glu
            180                 185                 190         
Glu Gln Lys Leu Tyr Trp Ala Asp Ala Lys Leu Asn Phe Ile His Lys
        195                 200                 205             
Ser Asn Leu Asp Gly Thr Asn Arg Gln Ala Val Val Lys Gly Ser Leu
    210                 215                 220                 
Pro His Pro Phe Ala Leu Thr Leu Phe Glu Asp Ile Leu Tyr Trp Thr
225                 230                 235                 240 
Asp Trp Ser Thr His Ser Ile Leu Ala Cys Asn Lys Tyr Thr Gly Glu
                245                 250                 255     
Gly Leu Arg Glu Ile His Ser Asp Ile Phe Ser Pro Met Asp Ile His
            260                 265                 270         
Ala Phe Ser Gln Gln Arg Gln Pro Asn Ala Thr Asn Pro Cys Gly Ile
        275                 280                 285             
Asp Asn Gly Gly Cys Ser His Leu Cys Leu Met Ser Pro Val Lys Pro
    290                 295                 300                 
Phe Tyr Gln Cys Ala Cys Pro Thr Gly Val Lys Leu Leu Glu Asn Gly
305                 310                 315                 320 
Lys Thr Cys Lys Asp Gly Ala Thr Glu Leu Leu Leu Leu Ala Arg Arg
                325                 330                 335     
Thr Asp Leu Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile
            340                 345                 350         
Val Leu Gln Leu Glu Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp
        355                 360                 365             
Pro Val Glu Gly Tyr Ile Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile
    370                 375                 380                 
Arg Arg Ser Phe Ile Asp Gly Ser Gly Ser Gln Phe Val Val Thr Ala
385                 390                 395                 400 
Gln Ile Ala His Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn
                405                 410                 415     
Leu Tyr Trp Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu
            420                 425                 430         
Asn Gly Thr Met Arg Lys Ile Leu Ile Ser Glu Asp Leu Glu Glu Pro
        435                 440                 445             
Arg Ala Ile Val Leu Asp Pro Met Val Gly Tyr Met Tyr Trp Thr Asp
    450                 455                 460                 
Trp Gly Glu Ile Pro Lys Ile Glu Arg Ala Ala Leu Asp Gly Ser Asp
465                 470                 475                 480 
Arg Val Val Leu Val Asn Thr Ser Leu Gly Trp Pro Asn Gly Leu Ala
                485                 490                 495     
Leu Asp Tyr Asp Glu Gly Lys Ile Tyr Trp Gly Asp Ala Lys Thr Asp
            500                 505                 510         
Lys Ile Glu Val Met Asn Thr Asp Gly Thr Gly Arg Arg Val Leu Val
        515                 520                 525             
Glu Asp Lys Ile Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Tyr
    530                 535                 540                 
Val Tyr Trp Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys
545                 550                 555                 560 
Arg Ser Ala Glu Arg Glu Val Ile Ile Asp Gln Leu Pro Asp Leu Met
                565                 570                 575     
Gly Leu Lys Ala Thr Asn Val His Arg Val Ile Gly Ser Asn Pro Cys
            580                 585                 590         
Ala Glu Glu Asn Gly Gly Cys Ser His Leu Cys Leu Tyr Arg Pro Gln
        595                 600                 605             
Gly Leu Arg Cys Ala Cys Pro Ile Gly Phe Glu Leu Ile Ser Asp Met
    610                 615                 620                 
Lys Thr Cys Ile Val Pro Glu Ala Phe Leu Leu Phe Ser Arg Arg Ala
625                 630                 635                 640 
Asp Ile Arg Arg Ile Ser Leu Glu Thr Asn Asn Asn Asn Val Ala Ile
                645                 650                 655     
Pro Leu Thr Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Thr
            660                 665                 670         
Asp Asn Arg Ile Tyr Trp Thr Asp Ile Ser Leu Lys Thr Ile Ser Arg
        675                 680                 685             
Ala Phe Met Asn Gly Ser Ala Leu Glu His Val Val Glu Phe Gly Leu
    690                 695                 700                 
Asp Tyr Pro Glu Gly Met Ala Val Asp Trp Leu Gly Lys Asn Leu Tyr
705                 710                 715                 720 
Trp Ala Asp Thr Gly Thr Asn Arg Ile Glu Val Ser Lys Leu Asp Gly
                725                 730                 735     
Gln His Arg Gln Val Leu Val Trp Lys Asp Leu Asp Ser Pro Arg Ala
            740                 745                 750         
Leu Ala Leu Asp Pro Ala Glu Gly Phe Met Tyr Trp Thr Glu Trp Gly
        755                 760                 765             
Gly Lys Pro Lys Ile Asp Arg Ala Ala Met Asp Gly Ser Glu Arg Thr
    770                 775                 780                 
Thr Leu Val Pro Asn Val Gly Arg Ala Asn Gly Leu Thr Ile Asp Tyr
785                 790                 795                 800 
Ala Lys Arg Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Leu Ile Glu
                805                 810                 815     
Ser Ser Asn Met Leu Gly Leu Asn Arg Glu Val Ile Ala Asp Asp Leu
            820                 825                 830         
Pro His Pro Phe Gly Leu Thr Gln Tyr Gln Asp Tyr Ile Tyr Trp Thr
        835                 840                 845             
Asp Trp Ser Arg Arg Ser Ile Glu Arg Ala Asn Lys Thr Ser Gly Gln
    850                 855                 860                 
Asn Arg Thr Ile Ile Gln Gly His Leu Asp Tyr Val Met Asp Ile Leu
865                 870                 875                 880 
Val Phe His Ser Ser Arg Gln Ser Gly Trp Asn Glu Cys Ala Ser Ser
                885                 890                 895     
Asn Gly His Cys Ser His Leu Cys Leu Ala Val Pro Val Gly Gly Phe
            900                 905                 910         
Val Cys Gly Cys Pro Ala His Tyr Ser Leu Asn Ala Asp Asn Arg Thr
        915                 920                 925             
Cys Ser Ala Pro Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile
    930                 935                 940                 
Asn Arg Met Val Ile Asp Glu Gln Gln Ser Pro Asp Ile Ile Leu Pro
945                 950                 955                 960 
Ile His Ser Leu Arg Asn Val Arg Ala Ile Asp Tyr Asp Pro Leu Asp
                965                 970                 975     
Lys Gln Leu Tyr Trp Ile Asp Ser Arg Gln Asn Met Ile Arg Lys Ala
            980                 985                 990         
Gln Glu Asp Gly Ser Gln Gly Phe Thr Val Val Val Ser Ser Val Pro
        995                 1000                1005            
Ser Gln Asn Leu Glu Ile Gln Pro Tyr Asp Leu Ser Ile Asp Ile Tyr
    1010                1015                1020                
Ser Arg Tyr Ile Tyr Trp Thr Cys Glu Ala Thr Asn Val Ile Asn Val
1025                1030                1035               1040 
Thr Arg Leu Asp Gly Arg Ser Val Gly Val Val Leu Lys Gly Glu Gln
                1045                1050                1055    
Asp Arg Pro Arg Ala Ile Val Val Asn Pro Glu Lys Gly Tyr Met Tyr
            1060                1065                1070        
Phe Thr Asn Leu Gln Glu Arg Ser Pro Lys Ile Glu Arg Ala Ala Leu
        1075                1080                1085            
Asp Gly Thr Glu Arg Glu Val Leu Phe Phe Ser Gly Leu Ser Lys Pro
    1090                1095                1100                
Ile Ala Leu Ala Leu Asp Ser Arg Leu Gly Lys Leu Phe Trp Ala Asp
1105                1110                1115               1120 
Ser Asp Leu Arg Arg Ile Glu Ser Ser Asp Leu Ser Gly Ala Asn Arg
                1125                1130                1135    
Ile Val Leu Glu Asp Ser Asn Ile Leu Gln Pro Val Gly Leu Thr Val
            1140                1145                1150        
Phe Glu Asn Trp Leu Tyr Trp Ile Asp Lys Gln Gln Gln Met Ile Glu
        1155                1160                1165            
Lys Ile Asp Met Thr Gly Arg Glu Gly Arg Thr Lys Val Gln Ala Arg
    1170                1175                1180                
Ile Ala Gln Leu Ser Asp Ile His Ala Val Lys Glu Leu Asn Leu Gln
1185                1190                1195               1200 
Glu Tyr Arg Gln His Pro Cys Ala Gln Asp Asn Gly Gly Cys Ser His
                1205                1210                1215    
Ile Cys Leu Val Lys Gly Asp Gly Thr Thr Arg Cys Ser Cys Pro Met
            1220                1225                1230        
His Leu Val Leu Leu Gln Asp Glu Leu Ser Cys Gly Glu Pro Pro Thr
        1235                1240                1245            
Cys Ser Pro Gln Gln Phe Thr Cys Phe Thr Gly Glu Ile Asp Cys Ile
    1250                1255                1260                
Pro Val Ala Trp Arg Cys Asp Gly Phe Thr Glu Cys Glu Asp His Ser
1265                1270                1275               1280 
Asp Glu Leu Asn Cys Pro Val Cys Ser Glu Ser Gln Phe Gln Cys Ala
                1285                1290                1295    
Ser Gly Gln Cys Ile Asp Gly Ala Leu Arg Cys Asn Gly Asp Ala Asn
            1300                1305                1310        
Cys Gln Asp Lys Ser Asp Glu Lys Asn Cys Glu Val Leu Cys Leu Ile
        1315                1320                1325            
Asp Gln Phe Arg Cys Ala Asn Gly Gln Cys Ile Gly Lys His Lys Lys
    1330                1335                1340                
Cys Asp His Asn Val Asp Cys Ser Asp Lys Ser Asp Glu Leu Asp Cys
1345                1350                1355               1360 
Tyr Pro Thr Glu Glu Pro Ala Pro Gln Ala Thr Asn Thr Val Gly Ser
                1365                1370                1375    
Val Ile Gly Val Ile Val Thr Ile Phe Val Ser Gly Thr Val Tyr Phe
            1380                1385                1390        
Ile Cys Gln Arg Met Leu Cys Pro Arg Met Lys Gly Asp Gly Glu Thr
        1395                1400                1405            
Met Thr Asn Asp Tyr Val Val His Gly Pro Ala Ser Val Pro Leu Gly
    1410                1415                1420                
Tyr Val Pro His Pro Ser Ser Leu Ser Gly Ser Leu Pro Gly Met Ser
1425                1430                1435               1440 
Arg Gly Lys Ser Met Ile Ser Ser Leu Ser Ile Met Gly Gly Ser Ser
                1445                1450                1455    
Gly Pro Pro Tyr Asp Arg Ala His Val Thr Gly Ala Ser Ser Ser Ser
            1460                1465                1470        
Ser Ser Ser Thr Lys Gly Thr Tyr Phe Pro Ala Ile Leu Asn Pro Pro
        1475                1480                1485            
Pro Ser Pro Ala Thr Glu Arg Ser His Tyr Thr Met Glu Phe Gly Tyr
    1490                1495                1500                
Ser Ser Asn Ser Pro Ser Thr His Arg Ser Tyr Ser Tyr Arg Pro Tyr
1505                1510                1515               1520 
Ser Tyr Arg His Phe Ala Pro Pro Thr Thr Pro Cys Ser Thr Asp Val
                1525                1530                1535    
Cys Asp Ser Asp Tyr Ala Pro Ser Arg Arg Met Thr Ser Val Ala Thr
            1540                1545                1550        
Ala Lys Gly Tyr Thr Ser Asp Leu Asn Tyr Asp Ser Glu Pro Val Pro
        1555                1560                1565            
Pro Pro Pro Thr Pro Arg Ser Gln Tyr Leu Ser Ala Glu Glu Asn Tyr
    1570                1575                1580                
Glu Ser Cys Pro Pro Ser Pro Tyr Thr Glu Arg Ser Tyr Ser His His
1585                1590                1595               1600 
Leu Tyr Pro Pro Pro Pro Ser Pro Cys Thr Asp Ser Ser
                1605                1610            


<210> 41
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Heavy Chain Amino Acid Sequence
      without leader

<400> 41
Gln Val Gln Leu Leu Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe Pro Gly Tyr
            20                  25                  30          
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Ala Asn Ser Gly Ala Thr Asn Tyr Ala Gln Asn Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Ala Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Glu Asp His Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
        115                 120                 125             
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
    130                 135                 140                 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
145                 150                 155                 160 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
            180                 185                 190         
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
        195                 200                 205             
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
225                 230                 235                 240 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                245                 250                 255     
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
            260                 265                 270         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
        275                 280                 285             
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    290                 295                 300                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
305                 310                 315                 320 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
                325                 330                 335     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
            340                 345                 350         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        355                 360                 365             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    370                 375                 380                 
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
385                 390                 395                 400 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                405                 410                 415     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            420                 425                 430         
Ser Leu Ser Pro Gly Lys
        435             


<210> 42
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody Light Chain Amino Acid Sequence
      without leader

<400> 42
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
            180                 185                 190         
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215         


<210> 43
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Heavy Chain Amino Acid Sequence
      without leader

<400> 43
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
        115                 120                 125             
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
    130                 135                 140                 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
145                 150                 155                 160 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
            180                 185                 190         
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
        195                 200                 205             
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
225                 230                 235                 240 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                245                 250                 255     
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
            260                 265                 270         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
        275                 280                 285             
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    290                 295                 300                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
305                 310                 315                 320 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
                325                 330                 335     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
            340                 345                 350         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        355                 360                 365             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    370                 375                 380                 
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
385                 390                 395                 400 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                405                 410                 415     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            420                 425                 430         
Ser Leu Ser Pro Gly Lys
        435             


<210> 44
<211> 218
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody Light Chain Amino Acid Sequence
      without leader

<400> 44
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Ala Asn Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser
                85                  90                  95      
Pro Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105                 110         
Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser
        115                 120                 125             
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
    130                 135                 140                 
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro
145                 150                 155                 160 
Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn
                165                 170                 175     
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
            180                 185                 190         
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
        195                 200                 205             
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215             


<210> 45
<211> 438
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Heavy Chain Amino Acid Sequence
      without leader

<400> 45
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser
            100                 105                 110         
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
        115                 120                 125             
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
    130                 135                 140                 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
145                 150                 155                 160 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
                165                 170                 175     
Leu Ser Ser Val Val Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr
            180                 185                 190         
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
        195                 200                 205             
Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro
    210                 215                 220                 
Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
225                 230                 235                 240 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
                245                 250                 255     
Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly
            260                 265                 270         
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn
        275                 280                 285             
Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
    290                 295                 300                 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro
305                 310                 315                 320 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu
                325                 330                 335     
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
            340                 345                 350         
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
        355                 360                 365             
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
    370                 375                 380                 
Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
385                 390                 395                 400 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                405                 410                 415     
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
            420                 425                 430         
Ser Leu Ser Pro Gly Lys
        435             


<210> 46
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody Light Chain Amino Acid Sequence
      without leader

<400> 46
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Ser Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu
        35                  40                  45              
Leu Ile Tyr Val Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ala Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Asn Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         
Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser
            180                 185                 190         
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser
    210                 215         


<210> 47
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody light chain variable region
      sequence

<400> 47
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95      
Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110         


<210> 48
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody light chain variable region
      sequence

<400> 48
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45              
Leu Ile Tyr Ala Asn Thr Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80  
Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Thr Ser
                85                  90                  95      
Pro Ser Ala Ser Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu
            100                 105                 110         
Gly
    


<210> 49
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody light chain variable region
      sequence

<400> 49
Gln Ala Val Leu Thr Gln Pro Ser Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15      
Arg Val Ser Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Arg Leu
        35                  40                  45              
Leu Ile Tyr Val Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Val Ile Ala Gly Leu
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                85                  90                  95      
Leu Asn Ala Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         


<210> 50
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody light chain variable region
      sequence

<400> 50
cagtctgtgc tgactcagcc accctcagcg tctggggccc cagggcagag ggtcaccatc 60
tcctgcactg ggagcagctc caacatcggg gctggttatg atgtacactg gtaccagcag 120
cttccaggag cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc 180
cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc 240
caggctgagg atgaggctga ttattattgc cagtcctatg acagcagcct gagtggttat 300
gtcttcggaa ctgggaccaa ggtcaccgtc ctaggt                           336

<210> 51
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody light chain variable region
      sequence

<400> 51
cagtctgtgt tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc 60
tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag 120
cttccaggaa cagcccccaa actcctcatc tatggttaca gcaatcggcc ctcaggggtc 180
cctgaccgat tctctggctc caagtctggc gcctcagcct ccctggccat cactgggctc 240
cggcctgacg atgaggctga ttactattgc cagtcctatg acaacagcct gagttcttat 300
gtcttcggag gtgggaccca gctcaccgtt ttaagt                           336

<210> 52
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody light chain variable region
      sequence

<400> 52
caggctgtgc tgactcagcc gtcctcagtg tctggggccc cagggcagag ggtcaccatc 60
tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag 120
cttccaggaa cagcccccaa actcctcatc tatgctaaca ccaatcggcc ctcagggatc 180
cctgaccgat tctctggctc caagtctggc acctcggcct ccctggccat cactgggctc 240
cagactgagg atgaggctga ttattactgc cagtcctatg acaccagccc gagtgcctct 300
tatgtcttcg gaactgggac caagctgacc gtcctaggt                        339

<210> 53
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody light chain variable region
      sequence

<400> 53
caggctgtgc tgactcagcc gtcctcagtg tctggggccc cagggcagag ggtctccatc 60
tcctgcactg ggagcagctc caacatcggg gcagcttatg atgtacactg gtaccagcag 120
cttccaggaa cagcccccag actcctcatc tatgttaaca acaatcggcc ctcaggggtc 180
cctgaccgat tctctggctc caagtcgggc acctcagcct ccctagtcat tgctgggctc 240
caggctgagg atgaggctga ttattactgc cagtcctatg acaatagtct gaatgcttat 300
gtcttcggaa ctgggaccaa gctgaccgtc ctaggt                           336

<210> 54
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody heavy chain variable region
      sequence

<400> 54
caggtgcagc tgttgcagtc tgcagcagag gtgaaaaagc ccggggagtc tctgaagatc 60
tcctgtaagg gttctggata cgactttccc ggctactatc tgcactgggt gcgacaggcc 120
cctggacaag gccttgagtg gatgggctgg atcaacgcta acagtggtgc cacaaattat 180
gcacagaact ttcagggcag ggtcaccatg accagggaca cgtccatcag cgcagcttac 240
atggagctga gcagcctgag atctgacgac acggccgtct attattgtac gagagaggac 300
cactggggcc gagggaccac ggtcaccgtc tcctca                           336

<210> 55
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-18 Antibody heavy chain variable region
      sequence

<400> 55
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc gactactata tacactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atccactcta acagtggcgc cacaacctat 180
gcacagaagt ttcaggccag ggtcaccatg agcagggaca cgtccagcag cacagcctac 240
atggagttga gcaggctgga atctgacgac acggccatgt atttttgttc gagagaggac 300
tactggggcc aaggaaccct ggtcaccgtc tcgagt                           336

<210> 56
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-59Antibody heavy chain variable region
      sequence

<400> 56
gaagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc gactactata tacactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atccactcta acagtggcgc cacaacctat 180
gcacagaagt ttcaggccag ggtcaccatg agcagggaca cgtccagcag cacagcctac 240
atggagttga gcaggctgga atctgacgac acggccatgt atttttgttc gagagaggac 300
tactggggca gagggacaat ggtcaccgtc tcgagt                           336

<210> 57
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody heavy chain variable region
      sequence

<400> 57
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60
tcctgcaagg cttctggata caccttcacc gactactata tacactgggt gcgacaggcc 120
cctggacaag ggcttgagtg gatgggatgg atccactcta acagtggcgc cacaacctat 180
gcacagaagt ttcaggccag ggtcaccatg agcagggaca cgtccagcag cacagcctac 240
atggagttga gcaggctgga atctgacgac acggccatgt atttttgttc gagagaggac 300
tactggggca aagggacaat ggtcaccgtc tcgagt                           336

<210> 58
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 Antibody heavy chain variable region
      sequence

<400> 58
Gln Val Gln Leu Leu Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Asp Phe Pro Gly Tyr
            20                  25                  30          
Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Ala Asn Ser Gly Ala Thr Asn Tyr Ala Gln Asn Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Ala Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Glu Asp His Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser
            100                 105                 110         


<210> 59
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 Antibody heavy chain variable region
      sequence

<400> 59
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Arg Gly Thr Met Val Thr Val Ser Ser
            100                 105                 110         


<210> 60
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 Antibody heavy chain variable region
      sequence

<400> 60
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile His Ser Asn Ser Gly Ala Thr Thr Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Ala Arg Val Thr Met Ser Arg Asp Thr Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Arg Leu Glu Ser Asp Asp Thr Ala Met Tyr Phe Cys
                85                  90                  95      
Ser Arg Glu Asp Tyr Trp Gly Lys Gly Thr Met Val Thr Val Ser Ser
            100                 105                 110         


<210> 61
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 LC CDR3

<400> 61
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Tyr
 1               5                  10  


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 LC CDR2

<400> 62
Ala Asn Thr Asn Arg Pro Ser
 1               5          


<210> 63
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-59 LC CDR3

<400> 63
Gln Ser Tyr Asp Thr Ser Pro Ser Ala Ser Tyr Val
 1               5                  10          


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 LC CDR1

<400> 64
Thr Gly Ser Ser Ser Asn Ile Gly Ala Ala Tyr Asp Val His
 1               5                  10                  


<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 LC CDR2

<400> 65
Val Asn Asn Asn Arg Pro Ser
 1               5          


<210> 66
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH2-80 LC CDR3

<400> 66
Gln Ser Tyr Asp Asn Ser Leu Asn Ala Tyr Val
 1               5                  10      


<210> 67
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 HC CDR1

<400> 67
Gly Tyr Tyr Leu His
 1               5  


<210> 68
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 HC CDR2

<400> 68
Trp Ile Asn Ala Asn Ser Gly Ala Thr Asn Tyr Ala Gln Asn Phe Gln
 1               5                  10                  15      
Gly
    


<210> 69
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> RH1-10 HC CDR3

<400> 69
Glu Asp His
 1          


<210> 70
<211> 211
<212> PRT
<213> Cynomologous Monkey

<220> 
<221> VARIANT        
<222> (1)...(211)
<223> Precursor DKK-4

<400> 70
Met Ala Ala Ala Val Leu Leu Gly Leu Ser Trp Leu Cys Ser Pro Leu
 1               5                  10                  15      
Ala Leu Val Leu Asp Phe Asn Asn Ile Arg Ser Ser Ala Asp Leu Gly
            20                  25                  30          
Ala Arg Lys Gly Ser Gln Cys Leu Ser Asp Thr Asp Cys Asn Arg Lys
        35                  40                  45              
Phe Cys Leu Gln Ser His Asn Glu Lys Pro Phe Cys Ala Cys Arg Gly
    50                  55                  60                  
Leu Gln Arg Arg Cys Gln Arg Asp Ala Met Cys Cys Gly Thr Leu Cys
65                  70                  75                  80  
Met Asn Asp Val Cys Thr Thr Met Glu Asp Ala Pro Lys Leu Glu Arg
                85                  90                  95      
Gln Leu Asp Glu Gln Asp Gly Thr His Ala Val Thr Thr Gly His Pro
            100                 105                 110         
Val Gln Glu Asn Gln Pro Lys Arg Lys Ser Ile Lys Lys Ser Gln Gly
        115                 120                 125             
Arg Lys Gly Gln Glu Gly Glu Ser Leu Arg Thr Phe Asp Cys Gly Pro
    130                 135                 140                 
Gly Leu Cys Cys Ala Arg His Trp Thr Lys Ile Cys Lys Pro Val Leu
145                 150                 155                 160 
Leu Glu Gly Gln Val Cys Arg Arg Gly His Lys Asp Thr Ala Gln Ala
                165                 170                 175     
Pro Glu Ile Phe Gln Cys Asp Cys Gly Pro Gly Leu Leu Cys Arg Ser
            180                 185                 190         
Gln Leu Thr Ser Gln Gln His Ala Arg Leu Arg Val Cys Gln Lys Ile
        195                 200                 205             
Glu Lys Leu
    210     


<210> 71
<211> 313
<212> PRT
<213> Artificial Sequence

<220> 
<223> Rhesus Dkk-2 Fusion protein

<220> 
<221> VARIANT        
<222> (1)...(158)
<223> Rhesus Dkk-1 N-terminal

<220> 
<221> VARIANT        
<222> (159)...(274)
<223> Rhesus Dkk-2 C-terminal

<220> 
<221> VARIANT        
<222> (275)...(313)
<223> Myc and His epitope tags

<400> 71
Met Met Ala Leu Gly Ala Ala Gly Ala Ala Arg Val Leu Val Ala Leu
 1               5                  10                  15      
Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr
            20                  25                  30          
Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro
        35                  40                  45              
Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro
    50                  55                  60                  
Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr
65                  70                  75                  80  
Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr
                85                  90                  95      
Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu
            100                 105                 110         
Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys
        115                 120                 125             
Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn
    130                 135                 140                 
Asn Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Thr
145                 150                 155                 160 
Arg His Arg Asp Arg Asn His Gly His Tyr Ser Asn His Asp Leu Gly
                165                 170                 175     
Trp Gln Asn Leu Gly Arg Pro His Thr Lys Met Ser His Ile Lys Gly
            180                 185                 190         
His Glu Gly Asp Pro Cys Leu Arg Ser Ser Asp Cys Ile Glu Gly Phe
        195                 200                 205             
Cys Cys Ala Arg His Phe Trp Thr Lys Ile Cys Lys Pro Val Leu His
    210                 215                 220                 
Gln Gly Glu Val Cys Thr Lys Gln Arg Lys Lys Gly Ser His Gly Leu
225                 230                 235                 240 
Glu Ile Phe Gln Arg Cys Asp Cys Ala Lys Gly Leu Ser Cys Lys Val
                245                 250                 255     
Trp Lys Asp Ala Thr Tyr Ser Ser Lys Ala Arg Leu His Val Cys Gln
            260                 265                 270         
Lys Ile Glu Phe Cys Thr Tyr Pro Ala Gln Trp Arg Pro Leu Glu Ser
        275                 280                 285             
Arg Gly Pro Phe Glu Gln Lys Leu Ile Ser Gly Gly Asp Leu Asn Met
    290                 295                 300                 
His Thr Glu His His His His His His
305                 310             

